Sci. STKE, 17 April 2007
Biochemistry Spotlight on the Pre-B Cell Receptor
Science, AAAS, Washington, DC 20005, USA
The pre-B cell receptor (pre-BCR), comprising a heavy chain and a heterodimeric surrogate light chain (SLC), is a signaling complex that acts as a checkpoint in B cell development. Bankovich et al. report the structure of a pre-BCR Fab-like fragment at 2.7 angstrom resolution. The structure shows how the requirement for pairing with the SLC might constrain the repertoire of heavy chains in the mature antibody population. The crystal structure, together with electron microscopy data and biochemical analysis, supports a model of antigen-independent SLC-mediated dimerization of the pre-BCR to promote pre-B cell activation and expansion.
Citation: V. Vinson, Spotlight on the Pre-B Cell Receptor. Sci. STKE 2007, tw137 (2007).
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