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Sci. STKE, 24 April 2007
Vol. 2007, Issue 383, p. pe16
[DOI: 10.1126/stke.3832007pe16]


What Is Left Behind—Quality Control in Germ Cell Migration

Bijan Boldajipour and Erez Raz*

Germ Cell Development, Max-Planck-Institute for Biophysical Chemistry, 37077 Göttingen, Germany and Institute of Cell Biology, Center for Molecular Biology of Inflammation (ZMBE), University of Münster, 48149 Münster, Germany.

Abstract: Cell differentiation, cell proliferation, cell death, and cell migration are tightly controlled during animal development and adult homeostasis. Failure to regulate these processes can result in tumor formation and metastasis. Aberrant cells are therefore often cleared by induction of cell death. Recent work has elucidated the mechanism of elimination of mouse primordial germ cells that fail to migrate properly and highlights the similarity of this mechanism to those governing the same phenomenon in Drosophila. In addition, these studies underscore the different functions a single signaling pathway can have in controlling cell survival, cell proliferation, and cell migration during different phases of development.

*Corresponding author. E-mail, eraz{at}

Citation: B. Boldajipour, E. Raz, What Is Left Behind—Quality Control in Germ Cell Migration. Sci. STKE 2007, pe16 (2007).

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