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Sci. STKE, 1 May 2007
Vol. 2007, Issue 384, p. eg4
[DOI: 10.1126/stke.3842007eg4]

EDITORIAL GUIDES

Focus Issue: Keeping the Immune Response in Check

John F. Foley1*, Elizabeth M. Adler1, and Nancy R. Gough2

1Associate Editor of Science's STKE,
2Editor of Science's STKE, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Summary: When exploring control of a biological system such as the inflammatory response, we often think first of mechanisms that promote activation of the system. But just as important are the signals that that modulate and terminate these processes. Unchecked recruitment and infiltration of leukocytes into tissues and the unrestrained production of pro-inflammatory cytokines and chemokines can lead to tissue damage and even cancer. This issue of Science’s STKE highlights studies that enhance our understanding of how pro-inflammatory signals are switched on, and--equally important--how they are switched off.

*Contact Information. E-mail: jfoley{at}aaas.org

Citation: J. F. Foley, E. M. Adler, N. R. Gough, Focus Issue: Keeping the Immune Response in Check. Sci. STKE 2007, eg4 (2007).

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