Sci. STKE, 1 May 2007
Molecular Biology The Heart of Stress Responses
Science, AAAS, Washington, DC 20005, USA
Two myosin heavy chain (MHC) genes are expressed in opposing manners in the mouse heart; MHC is expressed embryonically, whereas MHC is up-regulated postnatally. Cardiac stress shifts this ratio toward MHC with negative effects on cardiac function, and previous work has identified microRNAs (miRNAs) as possible regulators of cardiac growth and function. Van Rooij et al. now show that miR-208, which is encoded by an intron of the MHC gene, is a cardiac-specific regulator of MHC expression in response to stress and hypothyroidism in the heart. Deletion of the coding region of miR-208 resulted in inhibition of MHC expression and a reduced stress response in the heart. Thus, miR-208 may act through thyroid signaling to regulate MHC expression, possibly by repressing expression of the thyroid receptor coregulator THRAP1.
E. van Rooij, L. B. Sutherland, X. Qi, J. A. Richardson, J. Hill, E. N. Olson, Control of stress-dependent cardiac growth and gene expression by a microRNA. Science 316, 575-579 (2007). [Abstract] [Full Text]
Citation: B. Purnell, The Heart of Stress Responses. Sci. STKE 2007, tw153 (2007).
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