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Sci. STKE, 8 May 2007
Vol. 2007, Issue 385, p. tw162
[DOI: 10.1126/stke.3852007tw162]

EDITORS' CHOICE

Neuroscience Synaptic Communication

Peter Stern

Science, AAAS, Cambridge CB2 1LQ, UK

The traditional view of pyramidal neurons, which are excitatory, is that they can only excite their downstream target cells. However, Ren et al. report that cortical pyramidal neurons can elicit an inhibitory synaptic current in another neighboring pyramidal neuron. These unusual responses were caused by axo-axonic disynaptic connections onto {gamma}-aminobutyric acid (GABA)-releasing terminals located on or near the soma of the postsynaptic pyramidal cell. These so-called interpyramidal inhibitory postsynaptic currents were remarkably large and frequent, which suggests that they play an important role.

M. Ren, Y. Yoshimura, N. Takada, S. Horibe, Y. Komatsu, Specialized inhibitory synaptic actions between nearby neocortical pyramidal neurons. Science 316, 758-761 (2007). [Abstract] [Full Text]

Citation: P. Stern, Synaptic Communication. Sci. STKE 2007, tw162 (2007).


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