Sci. STKE, 8 May 2007
Neuroscience Synaptic Communication
Science, AAAS, Cambridge CB2 1LQ, UK
The traditional view of pyramidal neurons, which are excitatory, is that they can only excite their downstream target cells. However, Ren et al. report that cortical pyramidal neurons can elicit an inhibitory synaptic current in another neighboring pyramidal neuron. These unusual responses were caused by axo-axonic disynaptic connections onto -aminobutyric acid (GABA)-releasing terminals located on or near the soma of the postsynaptic pyramidal cell. These so-called interpyramidal inhibitory postsynaptic currents were remarkably large and frequent, which suggests that they play an important role.
Citation: P. Stern, Synaptic Communication. Sci. STKE 2007, tw162 (2007).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882