Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
STEM Talent Event

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Sci. STKE, 15 May 2007
Vol. 2007, Issue 386, p. tw170
[DOI: 10.1126/stke.3862007tw170]

EDITORS' CHOICE

Immunology Masterful Decisions

Stephen Simpson

Science, AAAS, Cambridge CB2 1LQ, UK

In the immune system, B and T lymphocytes develop via distinct pathways from common bone marrow progenitors, and the signaling protein Notch plays a crucial role in deciding T cell fate determination. Maeda et al. now find that a proto-oncogene called LRF represses this Notch signal and in so doing induces progenitors to undergo a B cell developmental program. Thus, LRF may act as a master regulator in the cell fate decision that generates the two main arms of the adaptive immune system.

T. Maeda, T. Merghoub, R. M. Hobbs, L. Dong, M. Maeda, J. Zakrzewski, M. R. M. van den Brink, A. Zelent, H. Shigematsu, K. Akashi, J. Teruya-Feldstein, G. Cattoretti, P. P. Pandolfi, Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. Science 316, 860-866 (2007). [Abstract] [Full Text]

I. Maillard, W. S. Pear, Keeping a tight leash on Notch. Science 316, 840-842 (2007). [Summary] [Full Text]

Citation: S. Simpson, Masterful Decisions. Sci. STKE 2007, tw170 (2007).

ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)