Sci. STKE, 26 June 2007
Genomics Tropical Disease Vector Genome
Barbara R. Jasny
Science, AAAS, Washington, DC 20005, USA
The mosquito Aedes aegypti is responsible for the transmission of dengue and yellow fever, which together affect more than 50 million people each year. Nene et al. (see the cover and see the Perspective by Chadee et al.) present the genome sequence for Ae. aegypti, which reveals extensive gene conservation with the malaria vector mosquito, Anopheles gambiae. As representatives of the two major mosquito subfamilies, the differences observed should underlie inherent biological traits, including blood-feeding preferences, host-seeking behavior, and the ability to transmit specific pathogens. Waterhouse et al. examined the evolution of innate immunity by comparing the genome of Ae. aegypti with that of the malaria mosquito, An. gambiae, and the fruit fly, Drosophila melanogaster, which represents a genetic outgroup. Different phases of immune signaling (recognition, modulation, signal transduction, transcriptional activation, and effector production) revealed different evolutionary dynamics.
V. Nene, J. R. Wortman, D. Lawson, B. Haas, C. Kodira, Z. (J.) Tu, B. Loftus, Z. Xi, K. Megy, M. Grabherr, Q. Ren, E. M. Zdobnov, N. F. Lobo, K. S. Campbell, S. E. Brown, M. F. Bonaldo, J. Zhu, S. P. Sinkins, D. G. Hogenkamp, P. Amedeo, P. Arensburger, P. W. Atkinson, S. Bidwell, J. Biedler, E. Birney, R. V. Bruggner, J. Costas, M. R. Coy, J. Crabtree, M. Crawford, B. deBruyn, D. DeCaprio, K. Eiglmeier, E. Eisenstadt, H. El-Dorry, W. M. Gelbart, S. L. Gomes, M. Hammond, L. I. Hannick, J. R. Hogan, M. H. Holmes, D. Jaffe, J. S. Johnston, R. C. Kennedy, H. Koo, S. Kravitz, E. V. Kriventseva, D. Kulp, K. LaButti, E. Lee, S. Li, D. D. Lovin, C. Mao, E. Mauceli, C. F. M. Menck, J. R. Miller, P. Montgomery, A. Mori, A. L. Nascimento, H. F. Naveira, C. Nusbaum, S. O'Leary, J. Orvis, M. Pertea, H. Quesneville, K. R. Reidenbach, Y.-H. Rogers, C. W. Roth, J. R. Schneider, M. Schatz, M. Shumway, M. Stanke, E. O. Stinson, J. M. C. Tubio, J. P. VanZee, S. Verjovski-Almeida, D. Werner, O. White, S. Wyder, Q. Zeng, Q. Zhao, Y. Zhao, C. A. Hill, A. S. Raikhel, M. B. Soares, D. L. Knudson, N. H. Lee, J. Galagan, S. L. Salzberg, I. T. Paulsen, G. Dimopoulos, F. H. Collins, B. Birren, C. M. Fraser-Liggett, D. W. Severson, Genome sequence of Aedes aegypti, a major arbovirus vector. Science 316, 1718-1723 (2007). [Abstract] [Full Text]
R. M. Waterhouse, E. V. Kriventseva, S. Meister, Z. Xi, K. S. Alvarez, L. C. Bartholomay, C. Barillas-Mury, G. Bian, S. Blandin, B. M. Christensen, Y. Dong, H. Jiang, M. R. Kanost, A. C. Koutsos, E. A. Levashina, J. Li, P. Ligoxygakis, R. M. MacCallum, G. F. Mayhew, A. Mendes, K. Michel, M. A. Osta, S. Paskewitz, S. W. Shin, D. Vlachou, L. Wang, W. Wei, L. Zheng, Z. Zou, D. W. Severson, A. S. Raikhel, F. C. Kafatos, G. Dimopoulos, E. M. Zdobnov, G. K. Christophides, Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes. Science 316, 1738-1743 (2007). [Abstract] [Full Text]
Citation: B. R. Jasny, Tropical Disease Vector Genome. Sci. STKE 2007, tw229 (2007).
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