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Sci. STKE, 3 July 2007
Vol. 2007, Issue 393, p. pe36
[DOI: 10.1126/stke.3932007pe36]


Foxp3 Is Required Throughout the Life of a Regulatory T Cell

Jared E. Lopes1,{dagger}, David M. Soper1,{dagger}, and Steven F. Ziegler1,2*

1Department of Immunology, University of Washington School of Medicine, Seattle, WA, 98195, USA.
2Immunology Program, Benaroya Research Institute, Seattle, WA 98101, USA.
{dagger}These authors contributed equally to this work.

Abstract: The forkhead family transcription factor Foxp3 is critical for the development and function of CD4+CD25+ regulatory T cells (Tregs). A series of reports have begun to shed light on the precise role of Foxp3 in the regulation of the Treg transcriptome. Foxp3 can bind to specific gene elements, thereby altering transcription of target genes directly, and Foxp3 can alter the expression of genes encoding other transcription factors, thereby having an indirect effect on the transcription of target genes. Cells retaining aspects of Treg differentiation persist in the absence of Foxp3, which is suggestive of a Foxp3-independent aspect of Treg biology.

*Corresponding author. E-mail: sziegler{at}

Citation: J. E. Lopes, D. M. Soper, S. F. Ziegler, Foxp3 Is Required Throughout the Life of a Regulatory T Cell. Sci. STKE 2007, pe36 (2007).

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