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Sci. STKE, 10 July 2007
Vol. 2007, Issue 394, p. jc1
[DOI: 10.1126/stke.3942007jc1]


Ceramide: From Embryos to Tumors

Iaroslav A. Savtchouk1*, Floyd J. Mattie2*, and Anne A. Ollis2

1Department of Biology, Pennsylvania State University, University Park, PA 16802, USA.
2Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.

Abstract: Ceramides are ubiquitous lipids that have important functions integral to apoptotic signaling. Several therapeutic agents currently exist that induce ceramide-dependent apoptosis in cancerous cells, and a number of enzymes involved in ceramide metabolism are beginning to be recognized as potential targets for cancer therapy. Recent research shows that evasion of ceramide-dependent apoptosis is essential at the earliest stages of embryonic development and is an important mechanism of multidrug resistance. Although ceramide-based strategies for treating cancer are promising, current data about ceramide-resistant tumors require further understanding of the role of ceramide in apoptosis.

*Corresponding authors. E-mail, ixs138{at}, fjm131{at}

Citation: I. A. Savtchouk, F. J. Mattie, A. A. Ollis, Ceramide: From Embryos to Tumors. Sci. STKE 2007, jc1 (2007).

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