Sci. STKE, 24 July 2007
Physiology Longevity on the Brain
Beverly A. Purnell
Science, AAAS, Washington, DC 20005, USA
Several studies show that loss-of-function mutations in the insulin-like signaling cascade extend the life span of worms and flies; however, equivalent mutations are associated with metabolic disease and fatal diabetes in mice. In contrast, calorie restriction or genetic strategies in mice that enhance insulin sensitivity lower the risk of age-related disease and extend life span. Taguchi et al. resolve these conflicting results by pointing to the brain as the site where reduced insulin-like signaling can extend mouse life span.
Citation: B. A. Purnell, Longevity on the Brain. Sci. STKE 2007, tw264 (2007).
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