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Sci. STKE, 7 August 2007
Vol. 2007, Issue 398, p. tw284
[DOI: 10.1126/stke.3982007tw284]

EDITORS' CHOICE

Cell Biology Insulin Signaling Up Close and Personal

L. Bryan Ray

Science, Science’s STKE, AAAS, Washington, DC 20005, USA

Novel quantitative methods are allowing the analysis of gene and protein expression in unprecedented detail. Dong et al. (see the Perspective by Kim) profiled protein abundance changes in response to perturbations of insulin and insulin-like growth factor-1 (IGF-1) signaling in Caenorhabditis elegans and identified 86 targets. More than half of the targets identified by this quantitative proteomics approach were not previously identified and may provide new insights into the mechanisms of diabetes and aging.

M.-Q. Dong, J. D. Venable, N. Au, T. Xu, S. K. Park, D. Cociorva, J. R. Johnson, A. Dillin, J. R. Yates III, Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Science 317, 660-663 (2007). [Abstract] [Full Text]

S. K. Kim, Proteins that promote long life. Science 317, 603-604 (2007). [Summary] [Full Text]

Citation: L. B. Ray, Insulin Signaling Up Close and Personal. Sci. STKE 2007, tw284 (2007).



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