Sci. STKE, 14 August 2007
Neuroscience Feeling the Itch
Elizabeth M. Adler
Science's STKE, AAAS, Washington, DC 20005, USA
The disagreeable nature of itching--defined as far back as the 17th century as an unpleasant skin sensation that elicits the urge to scratch--is apparent to anyone who has wandered into a clump of poison ivy or experienced a mosquito bite. The identity of the central mediator of this "unpleasant sensation," however, has been unclear. Sun and Chen found that, in mice, a subset of unmyelinated dorsal root ganglion neurons expressed gastrin-releasing peptide (GRP) and that the GRP receptor (GRPR) was specifically localized to lamina I of the dorsal horn of the spinal cord (locations and neuron type consistent with a possible role in mediating itch perception). Mutant mice lacking the GRPR showed responses to heat and pain that were comparable to those of wild-type mice, but they displayed an attenuated scratching response to various histamine-dependent and -independent pruritogenic stimuli. Injection of a GRPR agonist into the cerebrospinal fluid of wild-type mice elicited scratching, whereas injection of a GRPR antagonist inhibited scratching in response to pruritogenic stimuli. Thus, the authors conclude that, at the level of the spinal cord, the GRPR is a mediator of an itch-specific signaling pathway--information that may provide an avenue toward the effective therapy of chronic and intractable pruritis.
Y.-G. Sun, Z.-F. Chen, A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature 448, 700-703 (2007). [PubMed]
Citation: E. M. Adler, Feeling the Itch. Sci. STKE 2007, tw289 (2007).
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