Sci. STKE, 21 August 2007
Neuroscience Fleeting Memories
Science, AAAS, Cambridge CB2 1LQ, UK
How persistent is our memory, how is it maintained, and how can it be disrupted? It has recently been shown that PKM, a protein kinase C isoform, is critical for maintaining hippocampus-dependent spatial memory and long-term potentiation. Using a conditioning taste aversion paradigm, Shema et al. (see the news story by Miller) found that long-term memory could be erased by infusion of a PKM inhibitor, ZIP, into the insular cortex. The activity of PKM was specifically involved in the storage of memories but not in their acquisition.
Citation: P. Stern, Fleeting Memories. Sci. STKE 2007, tw303 (2007).
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