Sci. STKE, 21 August 2007
Neuroscience Understanding Selective Synapse Elimination
Stella M. Hurtley
Science, AAAS, Cambridge CB2 1LQ, UK
Synapse elimination is a hallmark of neural circuit maturation during development. Many synapses are eliminated after an initial phase of synapse formation. However, little is known about the molecular machinery that executes synaptic elimination or why certain synapses are selectively eliminated while other synapses persist and grow. Ding et al. (see the Perspective by Miller) examined synapse elimination in the nematode worm and found that a ubiquitin E3 ligase complex plays a key role. The activity of the ubiquitin-proteasome system was tightly regulated by a synaptic adhesion molecule, which protected certain synapses from selective elimination.
Citation: S. M. Hurtley, Understanding Selective Synapse Elimination. Sci. STKE 2007, tw305 (2007).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882