Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 28 August 2007
Vol. 2007, Issue 401, p. tw315
[DOI: 10.1126/stke.4012007tw315]


Biochemistry Let's Get Together

Valda J. Vinson

Science, AAAS, Washington, DC 20005, USA

Proteins in the eukaryotic plasma membrane mediate many different functions and are largely partitioned into clusters. Using the SNARE protein syntaxin 1 as an example, Sieber et al. (see the Perspective by White) investigate the mechanism of clustering using high-resolution optical imaging, quantitative biochemistry, and molecular dynamics simulations. Weak protein-protein interactions are balanced by steric repulsion to give densely crowded clusters containing about 75 syntaxins. Proteins within the cluster are immobile but can exchange with freely diffusing molecules. This conceptual framework likely applies to many other membrane proteins.

J. J. Sieber, K. I. Willig, C. Kutzner, C. Gerding-Reimers, B. Harke, G. Donnert, B. Rammner, C. Eggeling, S. W. Hell, H. Grubmüller, T. Lang, Anatomy and dynamics of a supramolecular membrane protein cluster. Science 317, 1072-1076 (2007). [Abstract] [Full Text]

S. H. White, Crowds of syntaxins. Science 317, 1045-1046 (2007). [Summary] [Full Text]

Citation: V. J. Vinson, Let's Get Together. Sci. STKE 2007, tw315 (2007).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882