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Sci. STKE, 4 September 2007
Vol. 2007, Issue 402, p. pe47
[DOI: 10.1126/stke.4022007pe47]

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Toll-Like Receptors in Brain Development and Homeostasis

Peter H. Larsen, Thomas H. Holm, and Trevor Owens*

Medical Biotechnology Center, University of Southern Denmark, Winsloewparken 25, DK-5000 Odense C, Denmark.

Abstract: Toll-like receptors (TLRs) are best known as initiators of the innate immune response to pathogens. Recent reports now reveal intriguing roles for TLRs in the central nervous system (CNS). These include the regulation of neuroinflammation and of neurite outgrowth. The archetypal Toll protein in Drosophila melanogaster was implicated in the development of the nervous system. Now similar functions have been uncovered for the mammalian orthologs, the TLRs. TLRs expressed on CNS glia and neurons may recognize endogenous ligands and participate both in development and in responses associated with CNS injury.

*Corresponding author. E-mail, towens{at}health.sdu.dk

Citation: P. H. Larsen, T. H. Holm, T. Owens, Toll-Like Receptors in Brain Development and Homeostasis. Sci. STKE 2007, pe47 (2007).

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