Sci. STKE, 25 September 2007
Structural Biology Transporting Zinc
Science, AAAS, Washington, DC 20005, USA
The divalent zinc cation is found in multiple guises in prokaryotic and eukaryotic cells. Lu and Fu (see the Perspective by Nies) present the 3.8 angstrom structure of YiiP, a bacterial membrane protein that imports Zn2+ by exchanging it for H+. The structure of YiiP is a Y-shaped homodimer, through which a presumptive pathway for Zn2+/H+ exchange can be discerned. YiiP is a member of the cation diffusion facilitator family of transport proteins. Another family member, ZnT-8, is expressed solely in pancreatic cells and has recently been associated with risk for type 2 diabetes.
Citation: G. Chin, Transporting Zinc. Sci. STKE 2007, tw346 (2007).
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