Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 2 October 2007
Vol. 2007, Issue 406, p. tw356
[DOI: 10.1126/stke.4062007tw356]


Neuroscience Neuronal Pathfinding

Pamela J. Hines

Science, AAAS, Washington, DC 20005, USA

During development, the growing tips of neurons must locate and identify their preferred targets. Neurons follow attractive and repulsive guidance signals to build a network to connect muscle activity to brain signals, sensory inputs to behavioral responses, and so on. Fujisawa et al. have now discovered another component, EVA-1, in the guidance system for neurons that fine-tunes the guidance signals sent and received by different neurons in the model organism Caenorhabditis elegans.

K. Fujisawa, J. L. Wrana, J. G. Culotti, The Slit receptor EVA-1 coactivates a SAX-3/Robo–mediated guidance signal in C. elegans. Science 317, 1934-1938 (2007). [Abstract] [Full Text]

Citation: P. J. Hines, Neuronal Pathfinding. Sci. STKE 2007, tw356 (2007).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882