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Sci. STKE, 2 October 2007
Vol. 2007, Issue 406, p. tw356
[DOI: 10.1126/stke.4062007tw356]

EDITORS' CHOICE

Neuroscience Neuronal Pathfinding

Pamela J. Hines

Science, AAAS, Washington, DC 20005, USA

During development, the growing tips of neurons must locate and identify their preferred targets. Neurons follow attractive and repulsive guidance signals to build a network to connect muscle activity to brain signals, sensory inputs to behavioral responses, and so on. Fujisawa et al. have now discovered another component, EVA-1, in the guidance system for neurons that fine-tunes the guidance signals sent and received by different neurons in the model organism Caenorhabditis elegans.

K. Fujisawa, J. L. Wrana, J. G. Culotti, The Slit receptor EVA-1 coactivates a SAX-3/Robo–mediated guidance signal in C. elegans. Science 317, 1934-1938 (2007). [Abstract] [Full Text]

Citation: P. J. Hines, Neuronal Pathfinding. Sci. STKE 2007, tw356 (2007).

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Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)