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Sci. STKE, 16 October 2007
Vol. 2007, Issue 408, p. pe57
[DOI: 10.1126/stke.4082007pe57]

PERSPECTIVES

P.S. to PS (Phosphatidylserine)–Pertinent Proteins in Apoptotic Cell Clearance

Robert A. Schlegel1 and Patrick Williamson2*

1Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.
2Department of Biology, MacGuire LSB 323, Amherst College, Amherst, MA 01002, USA.

Abstract: The psr protein has been proposed as the critical receptor that detects phosphatidylserine (PS) on the surface of apoptotic cells. However, for some time there has been evidence that this protein is not at the cell surface but in the nucleus. Now, the phenotype of a knockout of the Drosophila psr protein (dPSR) has discredited the identification altogether, lending impetus both to uncovering the real function of the protein and to identifying the real PS receptor. Interpretations of studies of two other genes supposedly involved in PS transport may be built on similarly shaky foundations.

*Corresponding author. E-mail, plwilliamson{at}amherst.edu

Citation: R. A. Schlegel, P. Williamson, P.S. to PS (Phosphatidylserine)–Pertinent Proteins in Apoptotic Cell Clearance. Sci. STKE 2007, pe57 (2007).

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