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Sci. STKE, 6 November 2007
Vol. 2007, Issue 411, p. tw408
[DOI: 10.1126/stke.4112007tw408]

EDITORS' CHOICE

Developmental Biology Dynamic Developmental Gene Regulation

Beverly A. Purnell

Science, AAAS, Washington, DC 20005, USA

Gene regulatory networks control metazoan development and determine which transcription factors will regulate which regulatory genes. However, development is a dynamic process that is driven by continuous change in time and space. Smith et al. now show how a network subcircuit controls a circular pattern of regulatory gene expression that sweeps outward from the vegetal pole of the sea urchin embryo and extinguishes its own activity in the more central regions to establish a dynamic regulatory pattern of gene expression.

J. Smith, C. Theodoris, E. H. Davidson, A gene regulatory network subcircuit drives a dynamic pattern of gene expression. Science 318, 794-797 (2007). [Abstract] [Full Text]

Citation: B. A. Purnell, Dynamic Developmental Gene Regulation. Sci. STKE 2007, tw408 (2007).



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