Sci. STKE, 6 November 2007
Developmental Biology Dynamic Developmental Gene Regulation
Beverly A. Purnell
Science, AAAS, Washington, DC 20005, USA
Gene regulatory networks control metazoan development and determine which transcription factors will regulate which regulatory genes. However, development is a dynamic process that is driven by continuous change in time and space. Smith et al. now show how a network subcircuit controls a circular pattern of regulatory gene expression that sweeps outward from the vegetal pole of the sea urchin embryo and extinguishes its own activity in the more central regions to establish a dynamic regulatory pattern of gene expression.
Citation: B. A. Purnell, Dynamic Developmental Gene Regulation. Sci. STKE 2007, tw408 (2007).
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