Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 13 November 2007
Vol. 2007, Issue 412, p. pe62
[DOI: 10.1126/stke.4122007pe62]


The Role of Intracellular Calcium and RhoA in Neuronal Migration

Clare H. Faux and John G. Parnavelas*

Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK.

Abstract: The successive steps involved in cell migration include extension of the leading process, followed by translocation of the soma and retraction of the trailing process. These events require the coordinated activity of various intracellular signaling mechanisms. Recent evidence suggests that the intracellular distribution of calcium ions and of the Rho guanosine triphosphatase (RhoGTPase), RhoA, are important components of these mechanisms. During migration, the growth cone of the leading process senses guidance cues present in the extracellular environment. These cues, acting through appropriate receptors on the growth cone, induce changes in the concentration of calcium, both in the growth cone and in the soma. These changes in the distribution of calcium cause a redistribution of intracellular RhoA and the eventual translocation of the soma. The trailing process is retracted as the cell moves forward.

*Corresponding author. Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. Telephone, +44-20-7679-3366; e-mail, j.parnavelas{at}

Citation: C. H. Faux, J. G. Parnavelas, The Role of Intracellular Calcium and RhoA in Neuronal Migration. Sci. STKE 2007, pe62 (2007).

Read the Full Text

Brefeldin A-inhibited Guanine Exchange Factor 2 Regulates Filamin A Phosphorylation and Neuronal Migration.
J. Zhang, J. Neal, G. Lian, B. Shi, R. J. Ferland, and V. Sheen (2012)
J. Neurosci. 32, 12619-12629
   Abstract »    Full Text »    PDF »
Emerging functions of myelin-associated proteins during development, neuronal plasticity, and neurodegeneration.
F. Llorens, V. Gil, and J. A. del Rio (2011)
FASEB J 25, 463-475
   Abstract »    Full Text »    PDF »
AQP4 knockout impairs proliferation, migration and neuronal differentiation of adult neural stem cells.
H. Kong, Y. Fan, J. Xie, J. Ding, L. Sha, X. Shi, X. Sun, and G. Hu (2008)
J. Cell Sci. 121, 4029-4036
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882