Sci. STKE, 13 November 2007
Cell Biology Life and Death Decisions
Stella M. Hurtley
Science, AAAS, Cambridge CB2 1LQ, UK
How do cells determine whether to live or die after exposure to stressors that cause misfolding of intracellular proteins? Lin et al. find that the IRE1 signaling branch of the unfolded protein response plays a key role in promoting cell survival after protein misfolding in the endoplasmic reticulum (ER). Human cells shut off IRE1 signaling after prolonged ER protein misfolding in order to enhance cell survival.
J. H. Lin, H. Li, D. Yasumura, H. R. Cohen, C. Zhang, B. Panning, K. M. Shokat, M. M. LaVail, P. Walter, IRE1 signaling affects cell fate during the unfolded protein response. Science 318, 944-949 (2007). [Abstract] [Full Text]
Citation: S. M. Hurtley, Life and Death Decisions. Sci. STKE 2007, tw412 (2007).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882