Sci. STKE, 13 November 2007
Microbiology Doing Double Duty
Stella M. Hurtley
Science, AAAS, Cambridge CB2 1LQ, UK
During intracellular vesicular trafficking, delivery of Rab guanosine triphosphatases (GTPases) to sites of activation involves their release from a guanine nucleotide dissociation inhibitor (GDI) by a so-called GDI displacement factor (GDF). The identification of GDFs has been difficult. Now Machner and Isberg provide evidence for the existence of such an activity, surprisingly in a bifunctional protein--a guanine nucleotide exchange protein associated with the formation of a replication vacuole by the intracellular pathogen Legionella pneumophila.
Citation: S. M. Hurtley, Doing Double Duty. Sci. STKE 2007, tw419 (2007).
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