Science Signaling Podcast: 5 January 2010

Michael B. Yaffe^{1, 2} and Annalisa M. VanHook³

¹ Chief Scientific Editor of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.
² Koch Institute for Integrative Cancer Research, Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
³ Associate Online Editor of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: This is a conversation with Michael Yaffe about Research Articles published by Science Signaling in 2009.

The editors suggest the following Related Resources on Science sites:

In Science Signaling

PODCASTS
Cell Biology
Science Signaling Podcast: 4 January 2011

Michael B. Yaffe and Annalisa M. VanHook (4 January 2011)
Sci. Signal. 4 (154), pc1. [DOI: 10.1126/scisignal.2001786]
 |  Abstract »  |  Full Text »  |  Podcast »

EDITORIAL GUIDES
Cell Biology
2009: Signaling Breakthroughs of the Year

Elizabeth M. Adler (5 January 2010)
Sci. Signal. 3 (103), eg1. [DOI: 10.1126/scisignal.3103eg1]
 |  Abstract »  |  Full Text »  |  PDF »

RESEARCH ARTICLES
Aging
mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

Chong Chen, Yu Liu, Yang Liu, and Pan Zheng (24 November 2009)
Sci. Signal. 2 (98), ra75. [DOI: 10.1126/scisignal.2000559]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Computational Biology
A Noisy Paracrine Signal Determines the Cellular NF-B Response to Lipopolysaccharide

Timothy K. Lee, Elissa M. Denny, Jayodita C. Sanghvi, Jahlionais E. Gaston, Nathaniel D. Maynard, Jacob J. Hughey, and Markus W. Covert (20 October 2009)
Sci. Signal. 2 (93), ra65. [DOI: 10.1126/scisignal.2000599]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Cancer
Tks5-Dependent, Nox-Mediated Generation of Reactive Oxygen Species Is Necessary for Invadopodia Formation

Begoña Diaz, Gidon Shani, Ian Pass, Diana Anderson, Manuela Quintavalle, and Sara A. Courtneidge (15 September 2009)
Sci. Signal. 2 (88), ra53. [DOI: 10.1126/scisignal.2000368]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Biochemistry
Novel p47^phox-Related Organizers Regulate Localized NADPH Oxidase 1 (Nox1) Activity

Davide Gianni, Begoña Diaz, Nicolas Taulet, Bruce Fowler, Sara A. Courtneidge, and Gary M. Bokoch (15 September 2009)
Sci. Signal. 2 (88), ra54. [DOI: 10.1126/scisignal.2000370]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Systems Biology
Therapeutically Targeting ErbB3: A Key Node in Ligand-Induced Activation of the ErbB Receptor–PI3K Axis

Birgit Schoeberl, Emily A. Pace, Jonathan B. Fitzgerald, Brian D. Harms, Lihui Xu, Lin Nie, Bryan Linggi, Ashish Kalra, Violette Paragas, Raghida Bukhalid, Viara Grantcharova, Neeraj Kohli, Kip A. West, Magdalena Leszczyniecka, Michael J. Feldhaus, Arthur J. Kudla, and Ulrik B. Nielsen (30 June 2009)
Sci. Signal. 2 (77), ra31. [DOI: 10.1126/scisignal.2000352]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

PROTOCOLS
Cell Biology
Using a Microfluidic Device for High-Content Analysis of Cell Signaling

Raymond Cheong, Chiaochun Joanne Wang, and Andre Levchenko (16 June 2009)
Sci. Signal. 2 (75), pl2. [DOI: 10.1126/scisignal.275pl2]
 |  Abstract »  |  Full Text »  |  PDF »

RESEARCH ARTICLES
Biochemistry
System-Wide Changes to SUMO Modifications in Response to Heat Shock

Filip Golebiowski, Ivan Matic, Michael H. Tatham, Christian Cole, Yili Yin, Akihiro Nakamura, Jürgen Cox, Geoffrey J. Barton, Matthias Mann, and Ronald T. Hay (26 May 2009)
Sci. Signal. 2 (72), ra24. [DOI: 10.1126/scisignal.2000282]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

EDITORIAL GUIDES
Systems Biology
"Omic" Risk Assessment

Michael B. Major and Randall T. Moon (26 May 2009)
Sci. Signal. 2 (72), eg7. [DOI: 10.1126/scisignal.272eg7]
 |  Abstract »  |  Full Text »  |  PDF »

RESEARCH ARTICLES
Cell Biology
Deciphering Signaling Outcomes from a System of Complex Networks

Robert C. Hsueh, Madhusudan Natarajan, Iain Fraser, Blake Pond, Jamie Liu, Susanne Mumby, Heping Han, Lily I. Jiang, Melvin I. Simon, Ronald Taussig, and Paul C. Sternweis (19 May 2009)
Sci. Signal. 2 (71), ra22. [DOI: 10.1126/scisignal.2000054]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »

RESEARCH ARTICLES
Computational Biology
Dynamic Signaling in the Hog1 MAPK Pathway Relies on High Basal Signal Transduction

Javier Macia, Sergi Regot, Tom Peeters, Núria Conde, Ricard Solé, and Francesc Posas (24 March 2009)
Sci. Signal. 2 (63), ra13. [DOI: 10.1126/scisignal.2000056]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Cell Biology
Obesity Increases Vascular Senescence and Susceptibility to Ischemic Injury Through Chronic Activation of Akt and mTOR

Chao-Yung Wang, Hyung-Hwan Kim, Yukio Hiroi, Naoki Sawada, Salvatore Salomone, Laura E. Benjamin, Kenneth Walsh, Michael A. Moskowitz, and James K. Liao (17 March 2009)
Sci. Signal. 2 (62), ra11. [DOI: 10.1126/scisignal.2000143]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Cancer
EGFR Signals to mTOR Through PKC and Independently of Akt in Glioma

Qi-Wen Fan, Christine Cheng, Zachary A. Knight, Daphne Haas-Kogan, David Stokoe, C. David James, Frank McCormick, Kevan M. Shokat, and William A. Weiss (27 January 2009)
Sci. Signal. 2 (55), ra4. [DOI: 10.1126/scisignal.2000014]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »