Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Sci. Signal., 12 January 2010
Vol. 3, Issue 104, p. re1
Basal Release of ATP: An Autocrine-Paracrine Mechanism for Cell Regulation
Ross Corriden and
Paul A. Insel*
Departments of Pharmacology and Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Cells release adenosine triphosphate (ATP), which activates plasma membrane–localized P2X and P2Y receptors and thereby modulates cellular function in an autocrine or paracrine manner. Release of ATP and the subsequent activation of P2 receptors help establish the basal level of activation (sometimes termed "the set point") for signal transduction pathways and regulate a wide array of responses that include tissue blood flow, ion transport, cell volume regulation, neuronal signaling, and host-pathogen interactions. Basal release and autocrine or paracrine responses to ATP are multifunctional, evolutionarily conserved, and provide an economical means for the modulation of cell, tissue, and organismal biology.
Seiji Hayashi, Akihiro Hazama, Amal K. Dutta, Ravshan Z. Sabirov, and Yasunobu Okada (9 November 2004) Sci. STKE2004 (258), pl14.
[DOI: 10.1126/stke.2582004pl14] |Abstract »|Full Text »|PDF »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
On the role of ATP release, ectoATPase activity, and extracellular ADP in the regulatory volume decrease of Huh-7 human hepatoma cells.
M. V. Espelt, F. de Tezanos Pinto, C. L. Alvarez, G. S. Alberti, J. Incicco, M. F. L. Denis, C. Davio, and P. J. Schwarzbaum (2013)
Am J Physiol Cell Physiol
|Abstract »|Full Text »|PDF »
Flow detection and calcium signalling in vascular endothelial cells.