Sci. Signal., 19 January 2010
Cell Biology Integrin G Protein
L. Bryan Ray
Science Signaling, AAAS, Washington, DC 20005, USA
Adhesion molecules known as integrins are found on the surface of cells. When integrins adhere to components of the extracellular matrix, they act as receptors and initiate signaling events within the cell. Gong et al. show that they do so in part by partnering with a signal-transducing protein called G13. Such alpha subunits of heterotrimeric guanine nucleotide–binding proteins are well known for transducing signals from the large class of G protein–coupled receptors but were not known to work with integrins, a different class of receptor. G13 appears to interact directly with the integrin IIbβ3 and to transmit signals that regulate cell spreading.
H. Gong, B. Shen, P. Flevaris, C. Chow, S. C.-T. Lam, T. A. Voyno-Yasenetskaya, T. Kozasa, X. Du, G protein subunit G13 binds to integrin IIbβ3 and mediates integrin "outside-in" signaling. Science 327, 340–343 (2010). [Abstract] [Full Text]
Citation: L. B. Ray, Integrin G Protein. Sci. Signal. 3, ec19 (2010).
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