Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. Signal., 19 January 2010
Vol. 3, Issue 105, p. ec19
[DOI: 10.1126/scisignal.3105ec19]


Cell Biology Integrin G Protein

L. Bryan Ray

Science Signaling, AAAS, Washington, DC 20005, USA

Adhesion molecules known as integrins are found on the surface of cells. When integrins adhere to components of the extracellular matrix, they act as receptors and initiate signaling events within the cell. Gong et al. show that they do so in part by partnering with a signal-transducing protein called G{alpha}13. Such alpha subunits of heterotrimeric guanine nucleotide–binding proteins are well known for transducing signals from the large class of G protein–coupled receptors but were not known to work with integrins, a different class of receptor. G{alpha}13 appears to interact directly with the integrin {alpha}IIbβ3 and to transmit signals that regulate cell spreading.

H. Gong, B. Shen, P. Flevaris, C. Chow, S. C.-T. Lam, T. A. Voyno-Yasenetskaya, T. Kozasa, X. Du, G protein subunit G{alpha}13 binds to integrin {alpha}IIbβ3 and mediates integrin "outside-in" signaling. Science 327, 340–343 (2010). [Abstract] [Full Text]

Citation: L. B. Ray, Integrin G Protein. Sci. Signal. 3, ec19 (2010).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882