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Sci. Signal., 19 January 2010
Vol. 3, Issue 105, p. pe3
[DOI: 10.1126/scisignal.3105pe3]

PERSPECTIVES

TAK-ling IKK Activation: "Ub" the Judge

Shelly M. Wuerzberger-Davis and Shigeki Miyamoto*

Department of Pharmacology, University of Wisconsin-Madison, 6159 Wisconsin Institute for Medical Research, 1111 Highland Avenue, Madison, WI 53705, USA.

Abstract: Investigation of the signaling events that lead to the activation of the transcription factor nuclear factor {kappa}B (NF-{kappa}B) has been a hotbed for the discovery of previously uncharacterized signaling mechanisms. The important role that nondegradative polyubiquitin chains play in these processes is now well recognized; however, precisely how they orchestrate NF-{kappa}B signaling is still a matter of much controversy. A recent study has challenged the dogmatic view by demonstrating that interleukin-1β (IL-1β), a major proinflammatory cytokine, activates two consecutive pathways, the "RING" and "zinc" pathways, to coordinate early and late activation of NF-{kappa}B, respectively. This study introduces a paradigm shift in the still-evolving mechanism of regulation of NF-{kappa}B.

* Corresponding author. E-mail, smiyamot{at}wisc.edu

Citation: S. M. Wuerzberger-Davis, S. Miyamoto, TAK-ling IKK Activation: "Ub" the Judge. Sci. Signal. 3, pe3 (2010).

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