Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 19 January 2010
Vol. 3, Issue 105, p. re2
[DOI: 10.1126/scisignal.3105re2]

REVIEWS

What Is the Function of the Dendritic Cell Side of the Immunological Synapse?

José Luis Rodríguez-Fernández*, Lorena Riol-Blanco{dagger}, and Cristina Delgado-Martín{dagger}

Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, C/ Ramiro de Maeztu, 9, 28040 Madrid, Spain.

{dagger} These authors contributed equally to this work.

Abstract: The adaptive immune response requires the formation of a specialized interface called the immunological synapse (IS), which is formed between a mature dendritic cell (DC) and a CD4+ T cell in the lymph node. The IS involves organized motifs formed by cell-surface and cytoplasmic molecules at both the DC side (IS-DC) and the T cell side (IS-T) of the IS. Most studies of the functions of the IS have focused on the IS-T; however, to understand the function(s) of the entire IS, it is also necessary to gain insight into the role(s) of the IS-DC. Unlike T cells, which upon their activation leave the lymph node and return to the circulation, DCs largely become apoptotic and die in the node region. This latter observation and the known stability of the IS, which may last for hours, is consistent with the hypothesis that one of the functions of the IS-DC could be the temporal inhibition of the apoptosis of DCs, which would enable the activation of clonal T cells in the lymph nodes. Here, we discuss experimental data supporting the latter hypothesis, as well as the concept that the IS-DC is a signaling region that contributes to the functions of the IS.

* Corresponding author. E-mail, rodrifer{at}cib.csic.es

Citation: J. L. Rodríguez-Fernández, L. Riol-Blanco, C. Delgado-Martín, What Is the Function of the Dendritic Cell Side of the Immunological Synapse? Sci. Signal. 3, re2 (2010).

Read the Full Text



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882