Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 16 March 2010
Vol. 3, Issue 113, p. ec81
[DOI: 10.1126/scisignal.3113ec81]

EDITORS' CHOICE

Biophysics Moving Signals

Valda Vinson

Science, AAAS, Washington, DC 20005, USA

Many types of human breast cancers overexpress a cell-surface receptor—EphA2—a tyrosine kinase activated by the ligand ephrin-A1 present on adjoining cells. Salaita et al. (see the Perspective by Paszek and Weaver) studied the regulation of mechanically stimulated EphA2 signaling by inducing intermembrane signaling between living EphA2-expressing human breast cancer cells and supported membranes displaying laterally mobile ephrin-A1. When the receptors engaged their ligands, they formed clusters that moved radially to the junction between the cells and the membranes. Physically impeding this movement altered the cellular response to ephrin-A1. Different breast cancer cell lines showed differences in receptor movement that correlated with their invasion potential—and might indicate their capacity for metastasis formation.

K. Salaita, P. M. Nair, R. S. Petit, R. M. Neve, D. Das, J. W. Gray, J. T. Groves, Restriction of receptor movement alters cellular response: Physical force sensing by EphA2. Science 327, 1380–1385 (2010). [Abstract] [Full Text]

M. Paszek, V. Weaver, Enforcing order on signaling. Science 327, 1335–1336 (2010). [Summary] [Full Text]

Citation: V. Vinson, Moving Signals. Sci. Signal. 3, ec81 (2010).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882