Sci. Signal., 16 March 2010
Modeling Steady As She Blows
L. Bryan Ray
Science, Science Signaling, AAAS, Washington, DC 20005, USA
A fundamental characteristic of many biological control networksis the capacity to maintain the concentration of a particular component at steady state within a narrow range despite variations in the amounts of other network components that might change as a result of environmental variables in the state of a cell. In a mathematical analysis, Shinar and Feinberg reveal the essential requirements of a network robust to perturbation. Using this method, the sources of robustness in two bacterial systems—one that functions in osmoregulation and another that controls carbon flux in metabolism—were explained.
Citation: L. B. Ray, Steady As She Blows. Sci. Signal. 3, ec84 (2010).
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