Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 27 April 2010
Vol. 3, Issue 119, p. jc4
[DOI: 10.1126/scisignal.3119jc4]


Costimulatory Role of CXCR4 with Pre-TCR and Its Crosstalk with PI3K in β-Selection of Thymocytes

J. Ashik Ahamed* and Periasamy Madhivadhani

Department of Bio-Medical Science, Bharathidasan University, Trichy 620 024, India.

Abstract: Chemokines were initially thought of only as regulators of the migration of developing thymocytes between different compartments of the thymus and were predicted also to be involved in early stages of thymocyte development. Recent data have suggested additional functions for the chemokine receptor CXCR4—a G protein–coupled receptor—in thymocyte development, particularly during the β-selection developmental checkpoint. Phosphotidylinositol 3-kinase interacts with the pre–T cell receptor and CXCR4 during migration, proliferation, and differentiation of developing thymocytes. CXCR4 and Notch signaling, along with inhibition of glycogen synthase kinase-3β (GSK-3β), are essential for the proliferation and differentiation of thymocytes during β-selection. Thus, a critical role of chemokines and its downstream signaling in the β-selection of thymocytes has been demonstrated.

* Corresponding author. E-mail, as_h_ik{at}

Citation: J. A. Ahamed, P. Madhivadhani, Costimulatory Role of CXCR4 with Pre-TCR and Its Crosstalk with PI3K in β-Selection of Thymocytes. Sci. Signal. 3, jc4 (2010).

Read the Full Text

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882