Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 18 May 2010
Vol. 3, Issue 122, p. pe17
[DOI: 10.1126/scisignal.3122pe17]


Gyrate: CCM3 Dances with a Different Angiogenic Partner

Laura A. Dyer1, Andrea L. Portbury1, and Cam Patterson1, 2*

1 Division of Cardiology and UNC McAllister Heart Institute, 8200 Medical Biomolecular Research Building, University of North Carolina, Chapel Hill, NC 27599–7126, USA.
2 Department of Medicine, University of North Carolina, Chapel Hill, NC 27599–7126, USA.

Abstract: A healthy vasculature is an essential component of development and is regulated by different signaling pathways. One of the most critical pathways involved is the vascular endothelial growth factor (VEGF) pathway. Components of this pathway serve as the first marker of primitive endothelial cells and are instrumental in inducing the initial differentiation of endothelial cells and later refining them into either arteries or veins. However, the regulation of VEGF signaling remains a mystery, with most studies focusing on the downstream components of this signaling cascade. New evidence shows that the protein cerebral cavernous malformation 3 (CCM3) is a key regulator of the VEGF pathway, bringing to light a previously unknown component of the VEGF signaling axis and opening the door to an exciting new era of vasculogenic research.

* Corresponding author. E-mail, cpatters{at}

Citation: L. A. Dyer, A. L. Portbury, C. Patterson, Gyrate: CCM3 Dances with a Different Angiogenic Partner. Sci. Signal. 3, pe17 (2010).

Read the Full Text

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882