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Sci. Signal., 8 June 2010
Vol. 3, Issue 125, p. pe20
Eradicating the Mediators of Neuronal Death with a Fine-Tooth Comb
R. Suzanne Zukin*
Dominick P. Purpura Department of Neuroscience, Rose F. Kennedy Center, Room 610, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Ischemic tolerance is an evolutionarily conserved form of cerebral plasticity in which a brief period of cerebral ischemia (called ischemic preconditioning) confers transient tolerance to a subsequent ischemic challenge in the brain. Polycomb group proteins are gene-silencing factors that are abundant and widely distributed during embryogenesis and are essential to epigenetic cellular memory, pluripotency, and stem cell self-renewal. New insight into the molecular mechanisms underlying ischemic tolerance is highlighted by the finding that ischemic preconditioning activates polycomb proteins in mature neurons. Polycomb proteins act through epigenetic gene silencing to eradicate potential mediators of neuronal death and promote cellular arrest, enabling mature neurons to survive ischemic stroke.
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Yan Liu, Fan Liu, Hao Yu, Xinyang Zhao, Goro Sashida, Anthony Deblasio, Michael Harr, Qing-Bai She, Zhenbang Chen, Hui-Kuan Lin, Silvana Di Giandomenico, Shannon E. Elf, Youyang Yang, Yasuhiko Miyata, Gang Huang, Silvia Menendez, Ingo K. Mellinghoff, Neal Rosen, Pier Paolo Pandolfi, Cyrus V. Hedvat, and Stephen D. Nimer (23 October 2012) Sci. Signal.5 (247), ra77.
[DOI: 10.1126/scisignal.2003199] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »