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Sci. Signal., 8 June 2010
Vol. 3, Issue 125, p. pe20
[DOI: 10.1126/scisignal.3125pe20]


Eradicating the Mediators of Neuronal Death with a Fine-Tooth Comb

R. Suzanne Zukin*

Dominick P. Purpura Department of Neuroscience, Rose F. Kennedy Center, Room 610, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

Abstract: Ischemic tolerance is an evolutionarily conserved form of cerebral plasticity in which a brief period of cerebral ischemia (called ischemic preconditioning) confers transient tolerance to a subsequent ischemic challenge in the brain. Polycomb group proteins are gene-silencing factors that are abundant and widely distributed during embryogenesis and are essential to epigenetic cellular memory, pluripotency, and stem cell self-renewal. New insight into the molecular mechanisms underlying ischemic tolerance is highlighted by the finding that ischemic preconditioning activates polycomb proteins in mature neurons. Polycomb proteins act through epigenetic gene silencing to eradicate potential mediators of neuronal death and promote cellular arrest, enabling mature neurons to survive ischemic stroke.

* Corresponding author. E-mail, suzanne.zukin{at}

Citation: R. S. Zukin, Eradicating the Mediators of Neuronal Death with a Fine-Tooth Comb. Sci. Signal. 3, pe20 (2010).

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K.-M. Noh, J.-Y. Hwang, A. Follenzi, R. Athanasiadou, T. Miyawaki, J. M. Greally, M. V. L. Bennett, and R. S. Zukin (2012)
PNAS 109, E962-E971
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Can Genes Modify Stroke Outcome and By What Mechanisms?.
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Stroke 43, 286-291
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The Repressor Element 1-Silencing Transcription Factor Is a Novel Molecular Target for the Neurotoxic Effect of the Polychlorinated Biphenyl Mixture Aroclor 1254 in Neuroblastoma SH-SY5Y Cells.
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