Sci. Signal., 22 June 2010
Virology Herpes Virus MiRNA Modulation
Science, AAAS, Washington, DC 20005, USA
Viruses use a number of strategies to manipulate the cells of their host to ensure a successful infection. Herpesvirus saimiri (HVS) generates highly conserved small noncoding RNAs HSUR 1 and HSUR 2, which modulate expression of a number of proteins in infected primate T cells. Cazalla et al. (see the Perspective by Pasquinelli) observed complementarity between HSUR sequences and the seed regions of three different microRNAs (miRNAs)—miR-142-3p, miR-27, and miR-16—and found that these HSURs could bind to the miRNAs. Furthermore, the level of mature miR-27 was modulated by binding to HSUR 1, which targeted the miRNA for degradation.
Citation: G. Riddihough, Herpes Virus MiRNA Modulation. Sci. Signal. 3, ec190 (2010).
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