Sci. Signal., 29 June 2010
Host-Pathogen Interactions Bacterial (Interferon)ce
Stella M. Hurtley
Science, AAAS, Cambridge CB2 1LQ, UK
Intracellular bacterial pathogens, such as Listeria monocytogenes, are detected in the cytosol of host immune cells, where they induce a host response that is often dependent on microbial secretion systems. Woodward et al. now show that L. monocytogenes produces and releases cyclic diadenosine monophosphate (c-di-AMP) into the host cytosol, which induces the production of host type I interferon. Because a number of intracellular pathogens contain the protein machinery to generate this nucleotide and also activate this same innate immune pathway, a common molecular mechanism may exist for host detection of cytosolic bacterial pathogens.
J. J. Woodward, A. T. Iavarone, D. A. Portnoy, c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response. Science 328, 1703–1705 (2010). [Abstract] [Full Text]
Citation: S. M. Hurtley, Bacterial (Interferon)ce. Sci. Signal. 3, ec200 (2010).
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