Focus Issue: The Evolution of Complexity

Nancy R. Gough^1* and Wei Wong²

¹ Editor, Science Signaling, AAAS, 1200 New York Avenue, N.W., Washington, DC 20005, USA.
² Associate Editor, Science Signaling, AAAS, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: With genomic and proteomic data sets in hand, scientists are beginning to understand how variation in signaling proteins and signaling networks influences the function of signaling pathways to regulate cellular behavior. These analyses have provided insight into how proteins have evolved, how biological networks have evolved, and how organisms have evolved. Not only do these discoveries inform us about evolution of life at different levels, but they also have the potential to help us understand human disease and begin to engineer signaling networks to achieve specified tasks.

* Corresponding author. E-mail, ngough{at}aaas.org.

The editors suggest the following Related Resources on Science sites:

In Science Signaling

RESEARCH ARTICLES
Evolution
Cross-Species Protein Interactome Mapping Reveals Species-Specific Wiring of Stress Response Pathways

Jishnu Das, Tommy V. Vo, Xiaomu Wei, Joseph C. Mellor, Virginia Tong, Andrew G. Degatano, Xiujuan Wang, Lihua Wang, Nicolas A. Cordero, Nathan Kruer-Zerhusen, Akihisa Matsuyama, Jeffrey A. Pleiss, Steven M. Lipkin, Minoru Yoshida, Frederick P. Roth, and Haiyuan Yu (21 May 2013)
Sci. Signal. 6 (276), ra38. [DOI: 10.1126/scisignal.2003350]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Evolution
Genomic Survey of Premetazoans Shows Deep Conservation of Cytoplasmic Tyrosine Kinases and Multiple Radiations of Receptor Tyrosine Kinases

Hiroshi Suga, Michael Dacre, Alex de Mendoza, Kamran Shalchian-Tabrizi, Gerard Manning, and Iñaki Ruiz-Trillo (1 May 2012)
Sci. Signal. 5 (222), ra35. [DOI: 10.1126/scisignal.2002733]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Evolution
The SH2 Domain–Containing Proteins in 21 Species Establish the Provenance and Scope of Phosphotyrosine Signaling in Eukaryotes

Bernard A. Liu, Eshana Shah, Karl Jablonowski, Andrew Stergachis, Brett Engelmann, and Piers D. Nash (6 December 2011)
Sci. Signal. 4 (202), ra83. [DOI: 10.1126/scisignal.2002105]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

EDITORIAL GUIDES
Evolution
Focus Issue: Evolution III—Domains for Change

Nancy R. Gough (14 September 2010)
Sci. Signal. 3 (139), eg8. [DOI: 10.1126/scisignal.3139eg8]
 |  Abstract »  |  Full Text »  |  PDF »  |  Evolution Series III »

PERSPECTIVES
Evolution
Domain Recombination: A Workhorse for Evolutionary Innovation

Gordana Apic and Robert B. Russell (14 September 2010)
Sci. Signal. 3 (139), pe30. [DOI: 10.1126/scisignal.3139pe30]
 |  Abstract »  |  Full Text »  |  PDF »

PERSPECTIVES
Protein Domains
Signals: Tinkering with Domains

Erich Bornberg-Bauer (14 September 2010)
Sci. Signal. 3 (139), pe31. [DOI: 10.1126/scisignal.3139pe31]
 |  Abstract »  |  Full Text »  |  PDF »