Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 29 June 2010
Vol. 3, Issue 128, p. pe23
[DOI: 10.1126/scisignal.3128pe23]

PERSPECTIVES

The Promise of Evolutionary Systems Biology: Lessons from Bacterial Chemotaxis

Orkun S. Soyer*

Systems Biology Program, School of Engineering, Computing and Mathematics, University of Exeter, Exeter EX4 4QF, UK.

Abstract: Bacterial chemotaxis and the signaling networks underlying it provide us with a model system for studying the molecular basis of behavior and information processing. Although chemotaxis is well characterized at both the phenotype and genotype levels in the model organism Escherichia coli, it is not yet possible to predict chemotaxis behavior in diverse bacteria on the basis of their environment or genome sequence. Moreover, we still cannot propose a plausible evolutionary trajectory from minimal systems to present-day chemotaxis networks. The analysis of all sequenced bacterial genomes provides a prediction of their chemotaxis networks and reveals substantial structural diversity. Additionally, it uncovers a set of previously unknown proteins that could be the "missing" link between complex present-day chemotaxis networks and simpler, ancestral systems composed of a few proteins. Further evaluation of these findings with experimental and modeling studies will allow us to distill evolutionary design principles in chemotaxis signaling networks.

* Corresponding author. E-mail, o.s.soyer{at}exeter.ac.uk

Citation: O. S. Soyer, The Promise of Evolutionary Systems Biology: Lessons from Bacterial Chemotaxis. Sci. Signal. 3, pe23 (2010).

Read the Full Text



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882