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Sci. Signal., 7 September 2010
Vol. 3, Issue 138, p. ec273
[DOI: 10.1126/scisignal.3138ec273]


Immunology Skin Reaction

Kristen L. Mueller

Science, AAAS, Washington, DC 20005, USA

Lymphocytes in the skin known as {gamma}{delta} T cells provide an important barrier against infection and injury. Unlike classical {alpha}β T cells, less is known about the molecular requirements of {gamma}{delta} T cell activation. Two studies demonstrate that the junctional adhesion molecule–like protein (JAML) is a costimulatory molecule for mouse {gamma}{delta} T cells. Witherden et al. (see the Perspective by Shaw and Huang) showed that JAML, binding to its ligand Coxsackie and adenovirus receptor (CAR), leads to proliferation, as well as cytokine and growth factor production by {gamma}{delta} T cells. In vivo, JAML-CAR interactions contributed to the wound-healing response in mice. Verdino et al. (see the Perspective by Shaw and Huang) present a crystal structure of CAR/JAML, which reveals an intracellular signaling motif similar to that known for the {alpha}β T cell costimulatory receptor that signals through phosphoinositide 3-kinase.

D. A. Witherden, P. Verdino, S. E. Rieder, O. Garijo, R. E. Mills, L. Teyton, W. H. Fischer, I. A. Wilson, W. L. Havran, The junctional adhesion molecule JAML is a costimulatory receptor for epithelial {gamma}{delta} T cell activation. Science 329, 1205–1210 (2010). [Abstract] [Full Text]

P. Verdino, D. A. Witherden, W. L. Havran, I. A. Wilson, The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K. Science 329, 1210–1214 (2010). [Abstract] [Full Text]

A. S. Shaw, Y. Huang, CAR’ing for the skin. Science 329, 1154–1155 (2010). [Summary] [Full Text]

Citation: K. L. Mueller, Skin Reaction. Sci. Signal. 3, ec273 (2010).

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