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Sci. Signal., 7 September 2010
Vol. 3, Issue 138, p. pe29
[DOI: 10.1126/scisignal.3138pe29]

PERSPECTIVES

NF-{kappa}B: Much Learned, Much to Learn

Bahram Razani1,2 and Genhong Cheng1*

1 Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, 609 Charles E. Young Drive East, Los Angeles, CA 90095, USA.
2 Medical Scientist Training Program, David Geffen School of Medicine at the University of California Los Angeles, 23-385 Center for the Health Sciences, Box 957041/MC:704117, Los Angeles, CA 90095, USA.

Abstract: Although NF-{kappa}B (nuclear factor {kappa}B) was discovered less than 25 years ago, it is one of the most well-studied transcription factors. It plays critical roles in various immune and cellular processes, and its dysregulation is a major driver of cancer and inflammatory pathology. A new book published by Cold Spring Harbor Laboratory Press, NF-{kappa}B: A Network Hub Controlling Immunity, Inflammation, and Cancer, provides a series of excellent reviews on the architecture, regulation, and pathophysiological roles of NF-{kappa}B signaling by some of the leading investigators in the field.

* Corresponding author. E-mail: gcheng{at}mednet.ucla.edu

Citation: B. Razani, G. Cheng, NF-{kappa}B: Much Learned, Much to Learn. Sci. Signal. 3, pe29 (2010).

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