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Sci. Signal., 21 September 2010
Vol. 3, Issue 140, p. pe32
[DOI: 10.1126/scisignal.3140pe32]


The Myelin Brake: When Enough Is Enough

Wendy B. Macklin*

Department of Cell and Developmental Biology, University of Colorado Denver Health Science Center, Aurora, CO 80045, USA.

Abstract: Myelination by Schwann cells in the peripheral nervous system and by oligodendrocytes in the central nervous system is tightly regulated by interactions with axons. Various investigations have shed light on the signaling pathways that mediate the production of myelin, but an important question remains; that is, which signals determine when the cell stops myelinating. New studies demonstrate that in Schwann cells, this is controlled by the abundance of Dlg1, which acts to stop active myelination.

* Corresponding author. Telephone, 303-724-3426; fax, 303-724-3420; e-mail, wendy.macklin{at}

Citation: W. B. Macklin, The Myelin Brake: When Enough Is Enough. Sci. Signal. 3, pe32 (2010).

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Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination.
M. E. Sheean, E. McShane, C. Cheret, J. Walcher, T. Muller, A. Wulf-Goldenberg, S. Hoelper, A. N. Garratt, M. Kruger, K. Rajewsky, et al. (2014)
Genes & Dev. 28, 290-303
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DDIT4/REDD1/RTP801 Is a Novel Negative Regulator of Schwann Cell Myelination.
R. Noseda, S. Belin, F. Piguet, I. Vaccari, S. Scarlino, P. Brambilla, F. M. Boneschi, M. L. Feltri, L. Wrabetz, A. Quattrini, et al. (2013)
J. Neurosci. 33, 15295-15305
   Abstract »    Full Text »    PDF »

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