Sci. Signal., 28 September 2010
Neuroscience -Synuclein and Aging
Stella M. Hurtley
Science, AAAS, Cambridge CB2 1LQ, UK
Transgenic -synuclein can reverse the otherwise lethal neurodegeneration of cysteine string protein- knockout mice via changes in SNARE proteins, which mediate synaptic vesicle release. Using experiments with purified recombinant proteins, triple β-synuclein knockout mice, and studies of mouse aging, Burré et al. now demonstrate that -synuclein directly interacts with the SNARE protein synaptobrevin and functions as a catalyst for SNARE-complex assembly. The role of synucleins is fully dispensable in young animals but becomes essential late in life, which suggests that -synuclein maintains normal synaptic function during aging.
Citation: S. M. Hurtley, -Synuclein and Aging. Sci. Signal. 3, ec303 (2010).
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