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Sci. Signal., 28 September 2010
Vol. 3, Issue 141, p. ra69
[DOI: 10.1126/scisignal.2001140]

RESEARCH ARTICLES

Signaling from the Endoplasmic Reticulum Activates Brassinosteroid Signaling and Promotes Acclimation to Stress in Arabidopsis

Ping Che1,2*, John D. Bussell1{dagger}, Wenxu Zhou1,2{dagger}, Gonzalo M. Estavillo3, Barry J. Pogson3, and Steven M. Smith1,2*

1 Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, Western Australia 6009, Australia.
2 Centre of Excellence for Plant Metabolomics, University of Western Australia, Crawley, Western Australia 6009, Australia.
3 Australian Research Council Centre of Excellence in Plant Energy Biology, Research School of Biology, Australian National University, Canberra, Australian Capital Territory 0200, Australia.

{dagger} These authors contributed equally to this work.

Abstract: The ability to acclimate to stresses enables plants to grow and develop under adverse environmental conditions. Regulated intramembrane proteolysis (RIP) triggered by endoplasmic reticulum (ER) stress mediates some forms of stress signaling. Brassinosteroids (BRs) have been implicated in plant adaptation to stress, but no mechanisms for activation have been discovered. Here, we reveal a connection between ER stress signaling and BR-mediated growth and stress acclimation. Arabidopsis transcription factors bZIP17 and bZIP28 were translocated from the ER through the Golgi, where they were proteolytically cleaved by site 2 protease and released to translocate into the nucleus. Stresses, including heat and inhibition of protein glycosylation, increased translocation of these two bZIPs to the nucleus. These nuclear-localized bZIPs not only activated ER chaperone genes but also activated BR signaling, which was required for stress acclimation and growth. Thus, these bZIPs link ER stress and BR signaling, which may be a mechanism by which plant growth and stress responses can be integrated.

* To whom correspondence should be addressed. E-mail: ssmith{at}cyllene.uwa.edu.au (S.M.S.); pche{at}cyllene.uwa.edu.au (P.C.)

Citation: P. Che, J. D. Bussell, W. Zhou, G. M. Estavillo, B. J. Pogson, S. M. Smith, Signaling from the Endoplasmic Reticulum Activates Brassinosteroid Signaling and Promotes Acclimation to Stress in Arabidopsis. Sci. Signal. 3, ra69 (2010).

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