Sci. Signal., 12 October 2010
Mitosis Location, Location, Location
Science, AAAS, Washington, DC 20005, USA
Cell division is orchestrated by a complex signaling pathway that ensures the correct segregation of newly replicated chromosomes to the two daughter cells. The pathway is controlled in part by restricting the activity of critical regulators to specific subcellular locations. For example, the chromosomal passenger complex (CPC) is recruited to chromosomes during mitosis, where it oversees kinetochore activity and cytokinesis (see Perspective by Musacchio). Wang et al., Kelly et al., and Yamagishi et al. now show that the phosphorylation of the chromatin protein, histone H3, acts to bring the CPC to chromosomes, thereby activating its Aurora B kinase subunit. The Survivin subunit of CPC binds specifically to phosphorylated H3, with the phosphorylation at centromeres being carried out by the mitosis-specific kinase, Haspin. Furthermore, Bub1 phosphorylation of histone H2A recruits shugoshin, a centromeric CPC adapter. Thus, these two histone marks in combination define the inner centromere.
F. Wang, J. Dai, J. R. Daum, E. Niedzialkowska, B. Banerjee, P. T. Stukenberg, G. J. Gorbsky, J. M. G. Higgins, Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis. Science 330, 231–235 (2010). [Abstract] [Full Text]
A. E. Kelly, C. Ghenoiu, J. Z. Xue, C. Zierhut, H. Kimura, H. Funabiki, Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase Aurora B. Science 330, 235–239 (2010). [Abstract] [Full Text]
Citation: G. Riddihough, Location, Location, Location. Sci. Signal. 3, ec316 (2010).
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