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Sci. Signal., 19 October 2010
Vol. 3, Issue 144, p. jc7
Role of Syntaxin 4 in Activity-Dependent Exocytosis and Synaptic Plasticity in Hippocampal Neurons
Ponnuswamy Mohanasundaram and
Muniesh Muthaiyan Shanmugam*
The authors are students in the Department of Biomedical Sciences, School of Basic Medical Sciences, Bharathidasan University, Tiruchirappalli, India.
Activity-dependent exocytosis of recycling endosomes that contain AMPA receptors in postsynaptic regions of hippocampal neurons occurs at microdomains enriched in the target SNARE [soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor] syntaxin 4 (Stx4). These Stx4-enriched domains are located near the postsynaptic density, and disrupting SNARE interactions involving Stx4 prevents the fusion of recycling endosomes that contain AMPA receptors in dendritic spines. AMPA receptor trafficking is important for long-term potentiation; thus, Stx4 is an essential postsynaptic component for synaptic plasticity in hippocampal neurons.