Sci. Signal., 2 November 2010
Immunology Innate Innit?
Kristen L. Mueller
Science, AAAS, Washington, DC 20005, USA
Innate lymphocytes (ILCs) are a recently described population of immune cells that produce cytokines like those associated with T helper cells but lack the recombined antigen receptors characteristic of T cells. Again, like some T helper cell lineages, a proportion of ILCs express the transcription factor RORt. These include lymphoid tissue–inducer (LTi) cells required for fetal lymphoid tissue organogenesis and a population of natural killer (NK)–like cells that function in gut immune responses. Sawa et al. (see the Perspective by Veldhoen and Withers) wondered whether the RORt-expressing ILCs all develop from the same progenitor population. Indeed, they found a fetal liver progenitor that gave rise to several phenotypically distinct populations. However, the LTi cells were not progenitors for the NK-like cells. It seems the trajectory of different ILC populations is developmentally regulated, and postnatally ILCs are favored that play a role in intestinal defense before the gut is fully colonized by intestinal microbiota.
S. Sawa, M. Cherrier, M. Lochner, N. Satoh-Takayama, H. J. Fehling, F. Langa, J. P. Di Santo, G. Eberl, Lineage relationship analysis of RORt+ innate lymphoid cells. Science 330, 665–669 (2010). [Abstract] [Full Text]
Citation: K. L. Mueller, Innate Innit? Sci. Signal. 3, ec339 (2010).
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