Focus Issue: Signals for Gene Expression

Wei Wong^1*

¹ Associate Editor of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: This Focus Issue of Science Signaling complements the Science Special Issue on Epigenetics (http://www.sciencemag.org/special/epigenetics/) with articles describing gene regulatory events. Highlights include signaling pathways that alter epigenetic patterning, transcriptional network organization, and posttranscriptional regulation of signaling molecules by microRNAs.

* Corresponding author. E-mail, wwong{at}aaas.org

The editors suggest the following Related Resources on Science sites:

In Science Signaling

PERSPECTIVES
Cancer
Histone Demethylases Set the Stage for Cancer Metastasis

Jian Cao and Qin Yan (30 April 2013)
Sci. Signal. 6 (273), pe15. [DOI: 10.1126/scisignal.2004188]
 |  Abstract »  |  Full Text »  |  PDF »

RESEARCH ARTICLES
Cancer
Epigenetic Activation of AP1 Promotes Squamous Cell Carcinoma Metastasis

Xiangming Ding, Hongya Pan, Jiong Li, Qi Zhong, Xiaohong Chen, Sarah M. Dry, and Cun-Yu Wang (30 April 2013)
Sci. Signal. 6 (273), ra28. [DOI: 10.1126/scisignal.2003884]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
MicroRNAs
Signaling by p38 MAPK Stimulates Nuclear Localization of the Microprocessor Component p68 for Processing of Selected Primary MicroRNAs

Sungguan Hong, Hyangsoon Noh, Haoming Chen, Ravi Padia, Zhixing K. Pan, Shi-Bing Su, Qing Jing, Han-Fei Ding, and Shuang Huang (12 March 2013)
Sci. Signal. 6 (266), ra16. [DOI: 10.1126/scisignal.2003706]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

EDITORS' CHOICE
Molecular Biology
Regulation in Reserve

Leslie K. Ferrarelli (8 January 2013)
Sci. Signal. 6 (257), ec7. [DOI: 10.1126/scisignal.2003943]
 |  Abstract »

EDITORS' CHOICE
Nuclear Receptors
Stable, But Transcriptionally Inactive

Nancy R. Gough (3 July 2012)
Sci. Signal. 5 (231), ec180. [DOI: 10.1126/scisignal.2003357]
 |  Abstract »

EDITORIAL GUIDES
Cell Biology
2011: Signaling Breakthroughs of the Year

Elizabeth M. Adler (3 January 2012)
Sci. Signal. 5 (205), eg1. [DOI: 10.1126/scisignal.2002787]
 |  Abstract »  |  Full Text »  |  PDF »

JOURNAL CLUB
Cancer Biology
MicroRNAs Add an Additional Layer to the Complexity of Cell Signaling

Jason I. Herschkowitz and Xiaoyong Fu (2 August 2011)
Sci. Signal. 4 (184), jc5. [DOI: 10.1126/scisignal.2002182]
 |  Abstract »  |  Full Text »  |  PDF »

EDITORS' CHOICE
Cell Biology
PIP-Influenced Transcription

Annalisa M. VanHook (10 May 2011)
Sci. Signal. 4 (172), ec132. [DOI: 10.1126/scisignal.4172ec132]
 |  Abstract »

PERSPECTIVES
Immunology
To Be or Not to Be a T_reg Cell: Lineage Decisions Controlled by Epigenetic Mechanisms

Aras Toker and Jochen Huehn (1 February 2011)
Sci. Signal. 4 (158), pe4. [DOI: 10.1126/scisignal.2001783]
 |  Abstract »  |  Full Text »  |  PDF »

EDITORIAL GUIDES
Cell Biology
2010: Signaling Breakthroughs of the Year

Elizabeth M. Adler (4 January 2011)
Sci. Signal. 4 (154), eg1. [DOI: 10.1126/scisignal.2001770]
 |  Abstract »  |  Full Text »  |  PDF »

In Science Magazine

INTRODUCTION TO SPECIAL ISSUE
Introduction
What Is Epigenetics?

Guy Riddihough and Laura M. Zahn (29 October 2010)
Science 330 (6004), 611. [DOI: 10.1126/science.330.6004.611]
 |  Full Text »  |  PDF »  |  Video »