Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 2 November 2010
Vol. 3, Issue 146, p. pe40
[DOI: 10.1126/scisignal.3146pe40]


Intracellular Delivery Strategies for MicroRNAs and Potential Therapies for Human Cardiovascular Diseases

Michael A. Shi and Guo-Ping Shi*

Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, NRB-7, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

Abstract: MicroRNAs (miRNAs) effectively regulate gene expression in cultured cells and human disease models, and such regulation can be blocked with antibodies against miRNAs if miRNA-associated adverse effects occur. Promising findings using miRNAs to prevent disease progression in animal studies give hope to patients with disorders caused by dysregulated gene expression, such as cardiovascular diseases. Inflammatory cell infiltration, endothelial cell dysfunction, and angiogenesis are common pathologies of cardiovascular diseases. Accumulating data suggest that miRNA-mediated inhibition of gene expression can drive these pathologies in cardiac tissue or vasculature. It is often desirable to deliver exogenously prepared miRNAs or antibodies against miRNAs to target genes or miRNAs in specific cell or tissue types. Because naked miRNAs or antibodies against miRNAs are often unstable in the circulation, investigation has focused on their packaging and efficient delivery to diseased organs.

* Corresponding author. Telephone, 617-525-4358; fax, 617-525-4380; e-mail, gshi{at}

Citation: M. A. Shi, G.-P. Shi, Intracellular Delivery Strategies for MicroRNAs and Potential Therapies for Human Cardiovascular Diseases. Sci. Signal. 3, pe40 (2010).

Read the Full Text

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882