Sci. Signal., 9 November 2010
Glia Tonic Inhibition
Peter R. Stern
Science, AAAS, Cambridge CB2 1LQ, UK
Neuronal inhibition has recently drawn much attention; however, the mechanisms involved in tonic release of and the cellular source of the neurotransmitter involved, -aminobutyric acid (GABA), have been difficult to pin down. Lee et al. showed that tonic release of GABA in the cerebellum occurs through the Bestrophin 1 anion channel of cerebellar astrocytes and Bergmann glial cells. These results confirm that glia can serve as a source of GABA for tonic inhibition of neurons and provide more evidence for interactions between neurons and glia cells that have implications for our understanding of brain-signaling mechanisms.
Citation: P. R. Stern, Tonic Inhibition. Sci. Signal. 3, ec344 (2010).
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