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Sci. Signal., 9 November 2010
Vol. 3, Issue 147, p. jc8
[DOI: 10.1126/scisignal.3147jc8]

JOURNAL CLUB

Grooming and Growing with Microglia

Joseph Mathew Antony*

The author is a postdoctoral fellow at the Department of Medical Biophysics, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5.

Abstract: Microglia mediate neuroprotection and neuropathogenesis but have not been directly associated with behavior. As gatekeepers of the brain’s immune system, microglia protect the brain from pathogens but also contribute to inflammation, which may negatively affect neurons. A recent study demonstrates a role for Hoxb8-expressing microglia in modulating behavior, a finding that is interesting from both the pathology and developmental biology perspectives.

* E-mail, joseph.antony{at}utoronto.ca

Citation: J. M. Antony, Grooming and Growing with Microglia. Sci. Signal. 3, jc8 (2010).

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