Science Signaling Podcast: 9 November 2010

R. Douglas Fields¹ and Annalisa M. VanHook²

¹ Nervous Systems Development and Plasticity Section, National Institute of Child Health and Human Development, National Institutes of Health, Building 35, Room 2A211, MSC 3713, 35 Lincoln Drive, Bethesda, MD 20892, USA.
² Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: This is a conversation with Doug Fields about a Research Article published in the 5 October 2010 issue of Science Signaling. Fields and Ni report that axonal swelling allows neurons to communicate with glia by releasing ATP through volume-activated anion channels. This nonvesicular, nonsynaptic form of communication may mediate activity-dependent communication between neurons and neighboring cells under normal conditions and may play a role in disease.

The editors suggest the following Related Resources on Science sites:

In Science Signaling

PODCASTS
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Maiken Nedergaard, Katsuhiko Mikoshiba, and Annalisa M. VanHook (10 April 2012)
Sci. Signal. 5 (219), pc8. [DOI: 10.1126/scisignal.2003064]
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RESEARCH ARTICLES
Cancer
Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma

Qi-Wen Fan, Christine Cheng, Chris Hackett, Morri Feldman, Benjamin T. Houseman, Theodore Nicolaides, Daphne Haas-Kogan, C. David James, Scott A. Oakes, Jayanta Debnath, Kevan M. Shokat, and William A. Weiss (9 November 2010)
Sci. Signal. 3 (147), ra81. [DOI: 10.1126/scisignal.2001017]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

EDITORIAL GUIDES
Neuroscience
Focus Issue: Getting Excited About Glia

Elizabeth M. Adler (9 November 2010)
Sci. Signal. 3 (147), eg11. [DOI: 10.1126/scisignal.3147eg11]
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JOURNAL CLUB
Neuroscience
Grooming and Growing with Microglia

Joseph Mathew Antony (9 November 2010)
Sci. Signal. 3 (147), jc8. [DOI: 10.1126/scisignal.3147jc8]
 |  Abstract »  |  Full Text »  |  PDF »

RESEARCH ARTICLES
Neuroscience
Nonsynaptic Communication Through ATP Release from Volume-Activated Anion Channels in Axons

R. Douglas Fields and Yingchun Ni (5 October 2010)
Sci. Signal. 3 (142), ra73. [DOI: 10.1126/scisignal.2001128]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »